PEMAZYRE (pemigatinib) tablets is a prescription medicine. PEMAZYRE (pemigatinib) tablets is used to treat advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2).
INDICATIONS AND USAGE
PEMAZYRE is a kinase inhibitor indicated for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test.
This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).
Manufactured By: Incyte Corporation
DOSAGE FORMS AND STRENGTHS: Tablets: 4.5 mg, 9 mg, and 13.5 mg
Prescribing Information URL: Click Here
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Pemigatinib (INN), sold under the brand name Pemazyre, is a medication for the treatment of adults with previously treated, unresectable locally advanced or metastatic bile duct cancer (cholangiocarcinoma) with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test. Pemigatinib works by blocking FGFR2 in tumor cells to prevent them from growing and spreading.
Pemigatinib belongs to a group of medicines called protein kinase inhibitors. It works by blocking enzymes known as protein kinases, particularly those that are part of receptors (targets) called fibroblast growth factor receptors (FGFRs). FGFRs are found on the surface of cancer cells and are involved in the growth and spread of the cancer cells. By blocking the tyrosine kinases in FGFRs, pemigatinib is expected to reduce the growth and spread of the cancer.